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KMID : 0616120100410010038
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Korean Journal of Pharmacognosy
2010 Volume.41 No. 1 p.38 ~ p.42
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Antibacterial Activity and Enhancing Antibiotic Effect of Extract and Fractions from Curcuma longa against MRSA Strain
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Lee Kyoung-In
Choi Cheol-Hee
Kim Sun-Min
Pyo Byoung-Sik
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Abstract
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Curcumin content of butanol fraction from C. longa was found to be 22.4942% of the highest content. However, in DPPH radical scavenging ability and antibacterial activity against methicillin resistance Staphylococcus aureu (MRSA, CCARM3696), ethylacetate fraction contained 2.5791% of curcumin was exhibited highest activity. In comparison of enhancing antibiotic(ampicillin) effect against MRSA, ethanol extract contained 1.7838% of curcumin showed more strong activity. This indicates that the ethanol extract and some fractions from C. longa can have antibacterial activity and enhancing antibiotic effect possibly without curcumin. Appropriate use of antimicrobial agent was important point prior to the development of new antibiotics. And in that sence, extract and fractions of C. longa were worth using as synergist of antibiotics and natural antimicrobial agent.
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KEYWORD
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Curcuma longa, MRSA, antibacterial activity, antibiotic
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